The Emerging Role of Sigma Receptors in Pain Medicine

Sigma receptors are protein chaperones with the unexpected characteristic of being activated by ligand binding. As such, they represent intriguing new targets for potential drug development. a chaperone, these “receptors” escort proteins from endoplasmic reticulum to their destinations and act correct misfolded proteins. The two subtypes sigma receptors, named σ1 σ2, markedly distinct each other. Agonists antagonists at show promise as targets, addressing range diseases including neurodegenerative disorders, cancer, cardiac may also be analgesic agents rehabilitation drugs opioid use disorder. an analgesic, seem more effective in treating neuropathic than nociceptive pain. New bifunctional compounds developed opioids, because targeting have opioid-sparing effect. pipeline based on is long treat things Fragile X syndrome Parkinson's disease Huntington’s cancer. A novel agent ADV502 acts high-affinity antagonist partial agonist µ-opioid receptor important both treatment cancer pain Since there has been little recent innovation medicine regarding that affect system promising encouraging.